STUDYING AND MANAGING GREAT RIVER FISHERIES: THE UPPER MISSISSIPPI RIVER EXPERIENCE Brian S. Ickes1, and James Garvey2 1US Geological Survey, Upper Midwest Environmental Science Center, La Crosse, WI 2Southern Illinois University, Carbondale, IL The largest rivers on Earth, herein termed Great Rivers, are notoriously difficult to study and manage, yet represent a nexus of freshwater fish diversity on the planet. Future conservation of freshwater fish diversity on the planet will depend, in large part, on the effectiveness of Great River research and the efficacy of Great River management. In our paper, we will discuss issues that challenge and presently constrain effective Great River fisheries research and management. In doing so, we will use the Upper Mississippi River as a case study given its status as perhaps the best studied and most intensively engineered Great River in the world. Our presentation will begin with a retrospective, time-sequenced history (> 100 years) of fishery research topics, research methods, and management techniques used in the basin. We will follow this with a presentation of selected contemporary case studies that pose vexing, yet pressing, research and management challenges. Finally, we will discuss future directions in Great River fisheries research and management. Keywords: Mississippi River, Illinois River, fisheries research, fisheries management